XPRK-聚咯胜太對DNA序列專一性研究

THUIR > College of Science > Department of Chemistry > National Research Council Research Report > Item 310901/11472

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Title:	XPRK-聚咯胜太對DNA序列專一性研究
Other Titles:	DNA Sequence-Specific Recognition of Peptides Containing XPRK-Polyamide Motifs
Authors:	佘亮 Sheh, Leung
Contributors:	行政院國家科學委員會東海大學化學系
Keywords:	含XPRK及聚口比咯(polyamide)多[月太];DNase I足跡法;DNA序列的專一性 Peptides incorporating the HPRK and polyamide motifs;DNase I footprinting;DNA sequence-specificity
Date:	2004
Issue Date:	2011-11-07T10:47:31Z (UTC)
Abstract:	本計畫將合成六種含XPRK 及聚口比咯(polyamide)多月太，並以DNase I 足跡法來研究其對DNA 序列的專一性。我們將以一條5』-32P-標記之158-mer 的Watson fragment 及互補的135-mer Crick fragment 來作定量足跡法，用以研究多月太對 DNA 的立體化學雙結合模式(bidentate interaction) 及單結合模式(single interaction)。此項研究將進一步探討多月太對DNA 序列專一性結合的立體化學基礎。
Relation:	研究編號：NSC93-2113-M029-003 研究期間：2004-08 ~ 2005-07
Appears in Collections:	[Department of Chemistry ] National Research Council Research Report

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