離子液體(或稱為熔融鹽)是一類低熔點的非分子溶劑。由於它們特殊的物理與化學性質，近年來離子液體已成功地被用做液相-液相萃取的溶劑、氣相層析管柱的固定相、與液相層析或毛細管電泳移動相的添加劑。本研究探討利用離子液體，1-ethyl-3-methylimidazolium tetrafluoroborate，當作毛細管電泳移動相的添加劑，進行九種tricyclicantidepressants藥物的同步分離實驗。結果顯示以50mM1-ethyl-3-methyl-imidazolium tetrafluoroborate溶液當作電泳移動相，可完全分離九種化合物。 Ionic liquids (also called molten salt) are a class of non-molecular ionic solvents with low melting point. Due to their special physical and chemical properties, ionic liquids have been used as an alternative solvent in liquid-liquid extraction, stationary phases in gas chromatographic column, and as additives in HPLC mobile phase and CE eluents. In this research, we investigate the use of 1-ethyl-3-methylimidazolium tetrafluoroborate as a CE additive for the simultaneous separation of nine tricyclic antidepressants. Results indicated that the nine tricyclic antidepressants can be completely separated using a CE eluent containing 50 mM 1-ethyl-3-methylimidazolium tetrafluoroborate. Effects of IL concentration, buffer pH, ionic strength and types of IL on the resolution of the nine TCAs were examined in detail.
