Herbal supplement ameliorates cardiac hypertrophy in rats with CCl 4 -induced liver cirrhosis

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题名:	Herbal supplement ameliorates cardiac hypertrophy in rats with CCl 4 -induced liver cirrhosis
作者:	Li, P.-C.ab , Chiu, Y.-W.cd , Lin, Y.-M.e , Day, C.H.f , Hwang, G.-Y.b , Pai, P.g , Tsai, F.-J.h , Tsai, C.-H.i , Kuo, Y.-C.j , Chang, H.-C.k , Liu, J.-Y.lm , Huang, C.-Y.h
贡献者:	Department of Life Science, Tunghai University
日期:	2012
上传时间:	2013-05-14T09:00:07Z (UTC)
摘要:	We used the carbon tetrachloride (CCl4) induced liver cirrhosis model to test the molecular mechanism of action involved in cirrhosis-associated cardiac hypertrophy and the effectiveness of Ocimum gratissimum extract (OGE) and silymarin against cardiac hypertrophy. We treated male wistar rats with CCl4 and either OGE (0.02 g/kg B.W. or 0.04 g/kg B.W.) or silymarin (0.2 g/kg B.W.). Cardiac eccentric hypertrophy was induced by CCl4 along with cirrhosis and increased expression of cardiac hypertrophy related genes NFAT, TAGA4, and NBP, and the interleukin-6 (IL-6) signaling pathway related genes MEK5, ERK5, JAK, and STAT3. OGE or silymarin co-treatment attenuated CCl4-induced cardiac abnormalities, and lowered expression of genes which were elevated by this hepatotoxin. Our results suggest that the IL-6 signaling pathway may be related to CCl4-induced cardiac hypertrophy. OGE and silymarin were able to lower liver fibrosis, which reduces the chance of cardiac hypertrophy perhaps by lowering the expressions of IL-6 signaling pathway related genes. We conclude that treatment of cirrhosis using herbal supplements is a viable option for protecting cardiac tissues against cirrhosis-related cardiac hypertrophy. ? 2012 Ping-Chun Li et al.
關聯:	Evidence-based Complementary and Alternative Medicine Volume 2012, 2012, Article number139045
显示于类别:	[生命科學系所] 期刊論文

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