Oxidative stress in nonallergic nasal polyps associated with bronchial hyperresponsiveness

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Please use this identifier to cite or link to this item: http://140.128.103.80:8080/handle/310901/21045

Title:	Oxidative stress in nonallergic nasal polyps associated with bronchial hyperresponsiveness
Authors:	Cheng, Y.-K.abg, Tsai, M.-H.c, Lin, C.-D.c, Hwang, G.-Y.b, Hang, L.-W.d, Tseng, G.-C.e, Shen, P.-S.f, Chang, W.-C.c
Contributors:	Department of Life Science, Tunghai University
Keywords:	Bronchial hyperresponsiveness;Chemiluminescence;Free radicals;Nasal polyps;Oxidative stress
Date:	2006
Issue Date:	2013-05-14T09:00:36Z (UTC)
Abstract:	Background: Nasal polyposis (NP) is a chronic inflammatory disease of upper airway with unknown etiology. NP is frequently associated with asthma; the interaction between these comorbidities remains interesting. Oxidative stress has been implicated in the pathophysiology of NP and asthma. The aim of this study is to investigate the significance of oxidative stress in sinonasal microenvironments by evaluating its association with clinopathological parameters and its impacts on the pathogenesis of bronchial hyperresponsiveness (BHR) in NP. Methods: Polyp biopsy specimens were obtained from 20 nonallergic patients; control mucosas were obtained from 20 volunteers. The levels of free radicals in the tissues and in blood were determined by a sensitive chemiluminescence (CL) method. NP patients were substratified into three subgroups, NP without BHR, NP with asymptomatic BHR, and NP with BHR and asthma by the results of provocative testing. Four histological characteristics of NP, inflammatory cells, eosinophil infiltration, edema and fibrosis were estimated and applied to correlate with the tissue-CL. Results: The mean CL level in polyp-tissues, but not in blood, was higher than in the control specimens. In NP patients, tissue-CL was associated with endoscopy score; high tissue-CL levels were positively correlated with the abundance of inflammatory cells and eosinophils. Tissue-CL and endoscopy score were associated with BHR/asthma phenotype. Conclusion: These results suggest an important role for oxidative stress in the pathophysiology of NP and a causal relation between oxidative stress and inflammatory cells, especially the eosinophils. Free radical levels in polyp-tissues associated with NP severity and with BHR/asthma phenotype in nonallergic NP patients. ? 2006 The Authors.
Relation:	Allergy: European Journal of Allergy and Clinical Immunology Volume 61, Issue 11, November 2006, Pages 1290-1298
Appears in Collections:	[生命科學系所] 期刊論文

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