Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide

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题名:	Structure-activity relationship of potent antimicrobial peptide analogs of Ixosin-B amide
作者:	Wu, Y.-S., Liao, Z.-J., Wang, K.-S., Lung, F.-D.T.
贡献者:	Department of Chemistry, Tunghai University
关键词:	Antimicrobial peptides Ixosin-B Antimicrobial activity Hemolytic activity
日期:	2013
上传时间:	2013-05-14T09:05:06Z (UTC)
摘要:	There is a great urgency in developing a new generation of antibiotics and antimicrobial agents since the bacterial resistance to antibiotics have increased dramatically. A series of overlapped peptide fragments of Ixosin-B, an antimicrobial peptide with amino acid sequence of QLKVDLWGTRSGIQPEQHSSGKSDVRRWRSRY, was designed, synthesized and examined for their antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. A potent 11-mer peptide TSG-8-1, WWSYVRRWRSR-amide, was developed, which exhibited antimicrobial activity against E. coli and S. aureus while very little hemolytic activity in human erythrocytes was observed at high dose level. This peptide could be further modified for the development of a potent antimicrobial agent in the future. ? 2013 Elsevier Ltd. All rights reserved.
關聯:	Bioorganic and Medicinal Chemistry Letters 23 (10) , pp. 2929-2932
显示于类别:	[化學系所] 期刊論文

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