聚己內酯[Poly(ε-caprolactone),PCL]、幾丁聚醣(chitosan)均具有生物相容性(biocompatibility)以及生物可分解性(biodegradable)，不論是材料本身或其共聚合物皆已被廣泛地使用在生醫領域。這兩種材料各自有其優缺點，聚己內酯擁有極佳的柔韌性，但機械強度不夠高，分解速率緩慢；而幾丁聚醣分解速率快，有較佳的熱穩定性，但是柔韌性不佳，由於上述所提及之缺點，而導致它們在使用上的限制。 本研究以溶液混合的方式，將疏水性的聚己內酯(PCL)分別以不同的比例添加進入親水性的天然高分子幾丁聚醣(CS)中，進而利用溶液澆鑄(casting from solvent)的方式製成生物可分解之摻合薄膜。由於聚己內酯與幾丁聚醣間無相容性，因此以接枝丙烯酸的聚己內酯共聚物PCL-g-AA取代PCL，進而探討PCL、PCL-g-AA與幾丁聚醣摻合薄膜的物性及相容性之影響。將基材與摻合物置入溶菌?的酵素環境中，來觀察材料的分解情形，進一?藉由DSC與XRD進行結晶度分析；傅立葉轉換紅外線光譜儀來確認兩者之間的鍵結情形；FESEM、OM觀察摻合物的型態；由拉伸試驗分析摻合物之機械性質。由實驗結果顯示，PCL-g-AA與CS間有共價鍵結產生，能有效的改善兩物質之間的相容性。 Poly ε-caprolactone (PCL)、chitosan (CS) and their copolymers have been widely studied and extensively applied in biomedical field. These two materials have their advantages and disadvantages. PCL with low mechanical strength and degradation rate shows good flexibility. Chitosan with low flexibility shows fast degradation rate. Their applications are limited due to their disadvantages. In this study, CS and PCL were blended in three different mass ratios as biodegradable composites and processed into membranes by a solution casting technique. The effects of replacing PCL with acrylic acid grafted PCL (PCL-g-AA) on the structure and properties of the composite were investigated. Furthermore, the properties of both PCL-g-AA/chitosan and PCL/chitosan were examined and compared using DSC, X-ray diffraction (XRD), FTIR, OM, SEM, tensile test and biodegradation test in the presence of lysozyme.
