Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus

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题名:	Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus
作者:	Yen, H.-W. , Hsiao, H.-P.
贡献者:	Department of Chemical and Materials Engineering, Tunghai University
关键词:	Dissolved oxygen;Morphology;Pellet;Rapamycin;Shear force
日期:	2013
上传时间:	2013-05-21T09:09:47Z (UTC)
摘要:	Rapamycin was known to have the functions of being an antibiotic and immunosuppressant; recently it was also recognized as being able to retard the aging process. The effects of dissolved oxygen (DO) level on rapamycin production by pellet-form of Streptomyces hygroscopi c us were investigated in this study. The results suggest that a high DO level is required to enhance rapamycin production. However, the premise for getting a high rapamycin concentration by using DO control was keeping the intact of pellet-form of S. hygroscopi c us. What if the high DO level achieved was coming from the increase of agitation; it might break down the morphology of pellets-form in the fermentation tank and result in the decrease of rapamycin production. The maximum rapamycin obtained in this study was about 780 mg/L in the 5 L fermentor batch with DO controlled over 30%, with the supplement of pure oxygen in the inlet gas, and the agitation speed limited to less than 200 rpm. Conclusively, a high DO level and the morphology of pellets form both were detrimental to achieving a high rapamycin production by S. hygroscopi c us in the agitation fermentor. ? 2013 The Society for Biotechnology, Japan.
關聯:	Journal of Bioscience and Bioengineering 2013
显示于类别:	[化學工程與材料工程學系所] 期刊論文

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