Host defense against Salmonella and rotaviral gastroenteritis: A serial study of transcriptional factors and cytokines

Tunghai University Institutional Repository > 理學院 > 生命科學系所 > 期刊論文 > Item 310901/23034

Please use this identifier to cite or link to this item: http://140.128.103.80:8080/handle/310901/23034

Title:	Host defense against Salmonella and rotaviral gastroenteritis: A serial study of transcriptional factors and cytokines
Authors:	Lin, A.-Y.a, Lin, C.-Y.bcd , Chen, C.-T.a, Chen, W.-L.a
Contributors:	Department of Life Science, Tunghai University
Keywords:	Cytokines;Interferon type II;Rotavirus;Salmonella;T-lymphocytes, helper-inducer
Date:	2008
Issue Date:	2013-05-30T09:07:58Z (UTC)
Abstract:	Background and Purpose: Common etiologies of acute enterocolitis in childhood include the intracellular pathogens Salmonella and rotavirus, along with extracellular pathogens. In order to elucidate differentiating immunologic parameters in patients with acute gastroenteritis of different etiologies, we investigated interferon (IFN)-gamma, interleukin (IL)-12, and T-bet of T-helper type 1 subsets, and IL-4 and GATA-3 of T-helper type 2 subsets. Methods: From June 1, 2003 to December 31, 2003, 32 patients with acute gastroenteritis were enrolled. Sequential heparinized blood samples were obtained on the day of presentation (day 1) and on day 3 of hospitalization. Using reverse transcriptase-polymerase chain reaction, the mean ratios of IFN-gamma, T-bet and IL-12 mRNA levels relative to beta-actin were determined. Results: Salmonella infections induced stronger IFN-gamma and T-bet responses than either rotavirus infection or other enterocolitis (p<0.05). However, poor IL-12 response in Salmonella infections implied failed T-helper type 1 immunity, and probably accounted for the prolonged clinical course. In contrast, by day 3 of hospitalization, most patients with rotavirus enterocolitis were symptom-free. Conclusions: IL-12 is the key factor in determining host response against and, hence, disease activity of Salmonella infections. ? 2008 Journal of Microbiology, Immunology and Infection.
Relation:	Journal of Microbiology, Immunology and Infection Volume 41, Issue 3, June 2008, Pages 265-271
Appears in Collections:	[生命科學系所] 期刊論文

Files in This Item:

File	Size	Format
index.html	0Kb	HTML	225	View/Open

Loading...