Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-μg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis. A rapid decline in intracameral concentration suggests that frequent supplementation of intracameral voriconazole may be required in clinical settings. Copyright ? 2009, American Society for Microbiology. All Rights Reserved.
Relation:
Antimicrobial Agents and Chemotherapy 53 (5) , pp. 2156-2157
