The effects of viscosity and aeration rate on rapamycin production in an airlift bioreactor by using Streptomyces hygroscopicus

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题名:	The effects of viscosity and aeration rate on rapamycin production in an airlift bioreactor by using Streptomyces hygroscopicus
作者:	Yen, H.-W.;Li, Y.-L.
贡献者:	Department of Chemical and Materials Engineering, Tunghai University
关键词:	Carbon source;CMC;Morphology;Rapamycin;Viscosity
日期:	2014
上传时间:	2014-05-30T02:01:52Z (UTC)
摘要:	The production of antibiotics by filamentous organisms is often dependent on the morphology and pellet size within the culture. An increase in viscosity by adding carboxymethylcellulose (CMC) could reduce pellet size and increase rapamycin production in the cultivation of Streptomyces hygroscopicus. A maximum yield of 410 mg/L of rapamycin was obtained when 3 g/L of CMC was added to a 5 L agitation bioreactor, as compared to 260 mg/L in the control batch (without the addition of CMC). Using an airlift bioreactor instead of an agitation tank can avoid the break-down of pellets due to the high shear force with the latter. The results indicate that an aeration rate of 1.5 vvm could achieve the maximum rapamycin production of 543 mg/L in an airlift bioreactor with 3 g/L of CMC adding. The application of both viscosity control and an airlift bioreactor has great potential with regard to commercialized rapamycin production. ? 2014 Taiwan Institute of Chemical Engineers.
關聯:	Journal of the Taiwan Institute of Chemical Engineers
显示于类别:	[化學工程與材料工程學系所] 期刊論文

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