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http://140.128.103.80:8080/handle/310901/24756
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| Title: | Lymphoma-associated hemophagocytic lymphohistiocytosis: Experience in adults from a single institution |
| Authors: | Yu, J.-T.;Wang, C.-Y.;Yang, Y.;Wang, R.-C.;Chang, K.-H.;Hwang, W.-L.;Teng, C.-L.J. |
| Contributors: | Department of Life Science, Tunghai University |
| Keywords: | Hematopoietic stem cell transplantation;Hemophagocytic lymphohistiocytosis;Lymphoma;Rituximab |
| Date: | 2013 |
| Issue Date: | 2014-05-30T02:11:40Z (UTC)
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| Abstract: | Lymphoma-associated hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disease. Differences between B cell and T cell lymphoma-associated HLH remain unclear, specifically clinical characteristics and survival. We retrospectively analyzed 30 lymphoma-associated HLH patients from July 2004 to October 2012. Patients were divided into B cell (n = 13) and T cell (n = 17) lymphoma groups. Patients' age, performance status, presence of Epstein-Barr virus infection, international prognostic index, presence of disseminated intravascular coagulopathy, serum triglyceride, fibrinogen, and lactate dehydrogenase levels were not significantly different between B cell and T cell lymphoma groups. HLH was an indicator for treatment resistance in patients with B cell (p = 0.048), but not T cell (p = 0.217), lymphoma. Patients in the T cell lymphoma group, however, had higher serum ferritin levels than patients in the B cell lymphoma group (11,525.6 versus 3,790.6 ng/mL; p = 0.043). The median survival time for patients in the B cell and T cell lymphoma groups was 330 and 96 days, respectively. Although the difference was not statistically significant (p = 0.273), our results suggested a trend toward a better overall survival time in patients with B cell lymphoma. This survival advantage could be at least partially due to use of rituximab (p = 0.045) for the treatment of patients with B cell lymphoma. Our results also suggested that allogeneic hematopoietic stem cell transplantation could possibly provide survival benefits to T cell lymphoma-associated HLH by graft-versus-lymphoma effect. ? 2013 Springer-Verlag Berlin Heidelberg. |
| Relation: | Annals of Hematology,Vol.92,Issue11,P.1529-1536 |
| Appears in Collections: | [生命科學系所] 期刊論文
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