本文主要探討應用多組成反應(multi-component reaction, MCRs)快速合成潛在性的生物分子。第一部份敘述使用2-哌啶甲酸(pipecolinic acid)作為試劑，並利用微波輔助多組成反應合成一系列pyrano[2,3-b]pyridines衍生物。第二部分也是利用微波輔助多組成反應快速合成一系列吡咯里西啶(pyrrolizidine)衍生物，並透過使用各種的醛組合出不同的官能基。第三部分則是將4-氯基-3-硝基香豆素和苯乙酮運用多組成反應合成氮呯(azepine)一系列的衍生物。 This thesis describes the application of multi-component reactions (MCRs) to the synthesis of potentially biologically active molecules. The first part discusses microwave-assisted synthesis of a series of pyrano[2,3-b]pyridines derivatives using pipecolic acid, aldehyde, and coumarin as the three substrates. The second part again describes the MCR synthesis of a series of pyrrolizidine derivatives through the combinations of different proline, aldehyde, and ,-unsaturated 1,3-indenedione under microwave irradiation conditions. The third part focuses on a pseudo three component reaction of 4-chloro-3-nitrocoumarin and acetophenone to afford azepine derivatives.
