Wu Zetian and Elizabeth I are famous female emperors in eastern and western countries. Their rising up is not only due to good luck. It was mainly because of their methods to deal with countries. In addition, their contributions are continuingly studied and discussed. We are amazed by the prosperous dynasties they created. Thus, we proposed two questions to conduct the report by comparison and contrast with reference of thesis, journals, books and internet resources. One question is that how did Wu Zetian and Elizabeth I rise from the dynasties dominated by men; the other one is that what are the similarities and differences between their ways of governance. Through these questions, we can know more deeply about these two empresses.