Herbal Supplement Ameliorates Cardiac Hypertrophy in Rats with CCl4-Induced Liver Cirrhosis.

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Title:	Herbal Supplement Ameliorates Cardiac Hypertrophy in Rats with CCl4-Induced Liver Cirrhosis.
Authors:	黃光裕 Li, Ping-Chun Chiu, Yung-Wei Lin, Yueh-Min Day, Cecilia Hsuan Hwang, Guang-Yuh Pai, Peiying Tsai, Fuu-Jen Tsai, Chang-Hai Kuo, Yu-Chun Hsiao-Chuan Chang, Liu, Jer-Yuh Huang, Chih-Yang
Contributors:	China Medical University Hospital Department of Life Science, Tunghai University Tungs’ Taichung MetroHarbor Hospital Chung Shan Medical University Changhua Christian Hospital MeiHo University Asia University
Keywords:	Herbal CCl4 interleukin-6
Date:	2012-08
Issue Date:	2016-08-16
Publisher:	Egypt:Hindawi Publishing Corporation
Abstract:	We used the carbon tetrachloride (CCl4) induced liver cirrhosis model to test the molecular mechanism of action involved in cirrhosis-associated cardiac hypertrophy and the effectiveness of Ocimum gratissimum extract (OGE) and silymarin against cardiac hypertrophy. We treated male wistar rats with CCl4 and either OGE (0.02 g/kg B.W. or 0.04 g/kg B.W.) or silymarin (0.2 g/kg B.W.). Cardiac eccentric hypertrophy was induced by CCl4 along with cirrhosis and increased expression of cardiac hypertrophy related genes NFAT, TAGA4, and NBP, and the interleukin-6 (IL-6) signaling pathway related genes MEK5, ERK5, JAK, and STAT3. OGE or silymarin co-treatment attenuated CCl4-induced cardiac abnormalities, and lowered expression of genes which were elevated by this hepatotoxin. Our results suggest that the IL-6 signaling pathway may be related to CCl4-induced cardiac hypertrophy. OGE and silymarin were able to lower liver fibrosis, which reduces the chance of cardiac hypertrophy perhaps by lowering the expressions of IL-6 signaling pathway related genes. We conclude that treatment of cirrhosis using herbal supplements is a viable option for protecting cardiac tissues against cirrhosis-related cardiac hypertrophy.
Relation:	Evidence-based complementary and alternative medicine, 2012, 139045
Appears in Collections:	[生命科學系所] 期刊論文

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