Lactate dehydrogenase, not vascular endothelium growth factor or basic fibroblast growth factor, positively correlates to bone marrow vascularity in acute myeloid leukemia.

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Title:	Lactate dehydrogenase, not vascular endothelium growth factor or basic fibroblast growth factor, positively correlates to bone marrow vascularity in acute myeloid leukemia.
Authors:	黃光裕 Teng, Chieh-Lin Young, Ji-Hsiung Hsu, Shih-Lan Chou, Guan Kuo, Ing-Tiau Yu, Chen-Yuan Hwang, Guang-Yuh
Contributors:	Taichung Veterans General Hospital Department of Life Sciences, Tunghai University Taipei Veterans General Hospital
Keywords:	acute myeloid leukemia angiogenesis basic fibroblast growth factor lactate dehydrogenase vascular endothelial growth factor
Date:	2006-11
Issue Date:	2016-08-17T01:30:08Z (UTC)
Publisher:	荷蘭:Elsevier
Abstract:	Background: Angiogenesis has been extensively studied in acute myeloid leukemia (AML). Lactate dehydrogenase (LDH), a common biochemical marker for tumor burden and anaerobic glycolysis, is a poor prognostic factor for AML. Regulated by hypoxia-induced factor, both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are responsive to cancer-related angiogenesis. To study the roles of serum LDH, VEGF and bFGF in AML angiogenesis, we investigated bone marrow vascularity in untreated AML patients, and analyzed its relationship to serum LDH, VEGF and bFGF levels. Methods: Eighteen (11 males, 7 females; mean age, 57.7 years) de novo, untreated AML patients were enrolled. Bone marrow vascularity was evaluated by staining bone marrow core biopsy tissue with endothelial cell marker CD31 or CD34. Serum LDH was determined with the Wroblewski-La Due method. Serum VEGF and bFGF were determined with enzyme-linked immunoassay. The relationship of LDH, VEGF and bFGF level to bone marrow vessel numbers was examined by linear regression. Results: Log LDH significantly correlated to AML bone marrow vascularity (r = 0.61; p = 0.007). VEGF and bFGF concentrations did not correlate with AML angiogenesis. Conclusion: These results suggest that serum LDH, but not VEGF and bFGF concentrations, can be used as a simple parameter for predicting vessel formation in AML bone marrow.
Relation:	Journal of the Chinese Medical Association, 69(11), 534-537
Appears in Collections:	[生命科學系所] 期刊論文

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