Universities, especially for technology transfer activities, always play the role of intermediaries in the innovation process. This study investigates three main issues related to open innovation based on bureaucratic perspective and scientific perspective. First, the protection power of technology is evaluated. Secondly, this study demonstrates determinants of successful technology transfer. Finally, this study examines the efficacy of technology transfer office in open innovation. Basing on literature reviews, we take the case study in Taiwan and try to make further insights for managing technology transfer in open innovation.