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http://140.128.103.80:8080/handle/310901/9139
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| Title: | Elevated titer and seropositivity of the antibody to human papillomavirus E6 protein in cervical cancer patients |
| Other Titles: | 子宮頸癌病患血清中具有高效價與高血清陽性率的抗人類乳突瘤病毒E6抗體 |
| Authors: | 郭展延;李致叡;鄭瓊姬;張智翔;陳子和;蔡玉真;黃光裕
Kuol, Chan-Yen;Lee, Chih-Jui;Cheng,Chiung-Chi;Chang,Chih-Hsiang;Chen, Tze-Ho;Tsai, Yu-Chen;Hwang, Guang-Yuh |
| Contributors: | 東海大學理學院 |
| Keywords: | Human Papilloma Viruses (HPV), Cervical Cancer, anti-E6 antibody |
| Date: | 2010-11-01 |
| Issue Date: | 2011-06-16T03:59:49Z (UTC)
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| Publisher: | 台中市：東海大學 |
| Abstract: | Development of cervical cancer is associated with human papillomavirus (HPV)
infection. However, data on comparison among the antibodies of anti-E6, anti-E7,
and anti-L1 in the sera of patients with cervical cancer or HPV infection are very
limited. In this study, we examined the expression of HPV-18 nonstructural proteins
E6, E7, and the major capsid L1 protein in tissues from 25 patients with cervical cancer
at stages ranging from Ib to IIa, based on the FIGO staging system. We also used
ELISA to assess the antibodies against the HPV-18 E6, E7, and L1 proteins in the sera
of these patients (patients) and in the sera of 20 healthy individuals (normal). Western
blotting and immunohistochemical staining of these tissues confirmed the presence of
the E6, E7, and L1 proteins. As compared to the normal controls, the patients’ sera
showed higher binding of the anti-E6, anti-E7, and anti-L1 antibodies. The anti-E6
and anti-E7 antibodies showed stronger binding than anti-L1 among all the 25 sera
samples tested. The seropositive percentage of anti-E6 (88%) was higher than that of
anti-E7 (32%) and anti-L1 (48%). These data suggest that elevated titer and
seropositivity of the antibody to human papillomavirus E6 protein in the sera of
cervical cancer patients. Interestingly, we also found that the 19 patients who
indicated as anti-E6 seropositivity had a lower 5-year cumulate survival outcome. |
| Relation: | 東海科學第13卷, p.1-16 |
| Appears in Collections: | [理學院] (校內出版品)東海科學
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| 13-1.pdf | 419Kb | Adobe PDF | 932 | View/Open |
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