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    Please use this identifier to cite or link to this item: http://140.128.103.80:8080/handle/310901/11472


    Title: XPRK-聚咯胜太對DNA序列專一性研究
    Other Titles: DNA Sequence-Specific Recognition of Peptides Containing XPRK-Polyamide Motifs
    Authors: 佘亮
    Sheh, Leung
    Contributors: 行政院國家科學委員會
    東海大學化學系
    Keywords: 含XPRK及聚口比咯(polyamide)多[月太];DNase I足跡法;DNA序列的專一性
    Peptides incorporating the HPRK and polyamide motifs;DNase I footprinting;DNA sequence-specificity
    Date: 2004
    Issue Date: 2011-11-07T10:47:31Z (UTC)
    Abstract: 本計畫將合成六種含XPRK 及聚口比咯(polyamide)多月太,並以DNase I 足跡法來研究其對DNA 序列的專一性。我們將以一條5』-32P-標記之158-mer 的Watson fragment 及互補的135-mer Crick fragment 來作定量足跡法,用以研究多月太對 DNA 的立體化學雙結合模式(bidentate interaction) 及單結合模式(single interaction)。此項研究將進一步探討多月太對DNA 序列專一性結合的立體化學基礎。
    Relation: 研究編號:NSC93-2113-M029-003
    研究期間:2004-08 ~ 2005-07
    Appears in Collections:[化學系所] 國科會研究報告

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